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The Mwandi Christian Hospital is located in the village of Mwandi, on the Zambezi River, midway between Livingstone and Sesheke, in the southwest corner of Zambia. The hospital is a mission of the United Church of Zambia, which has been assisted in this work by the Presbyterian Church (USA), the Medical Benevolence Foundation, and Medical Missions, Inc. of Columbia, South Carolina. In addition, a management team, operating out of the Thyatira Presbyterian Church at Mill Bridge, Salisbury, N.C., provides leadership and logistical support, and guides the fund raising efforts for the hospital community.

Hospitals in Zambia generally fall into three categories: those that are government hospitals, those that are private, and privately funded (some of which are religiously sponsored), and those which are owned and operated by a church, but with some governmental funding support. The Mwandi Christian Hospital falls into this last category. Thus, though it is owned and managed by the United Church of Zambia, now with assistance of Presbyterians in the United States, it also receives governmental funding to pay the operating costs and salaries.